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(Eli Lillys tirzepatide drug Zepbound and Novo Nordisks semaglutide drug Wegovy are FDA-approved for weight loss, containing higher dosages of the active ingredient.) Researchers evaluated on-treatment weight loss and the occurrence of gastrointestinal (GI) side effects in participants, who were either overweight or had obesity

Future studies should focus on developing more effective and safer treatments and optimizing multimodal therapeutic strategies to improve pain management and patient quality of life

10.1016/S1875-5364(23)60399-1 38 HuanD

These molecules are used experimentally both in vitro and in vivo

GLP-1 receptor agonists are approved primarily for type 2 diabetes and, in some formulations, for weight management

Some patients successfully transition to lower maintenance doses, while others require ongoing therapeutic dosing