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Ferroptosis, a distinct form of cell death driven by oxidative stress, has been implicated in the pathogenesis of various central nervous system disorders, including Parkinsons disease (Zhao et al., 2020), Alzheimers disease (Lane et al., 2021), Huntingtons disease (Skouta et al., 2014), epilepsy (Cai and Yang, 2021), and traumatic brain injury (Rui et al., 2021)

J Oral Biol Craniofacial Res

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Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11

Furthermore, a prior study found that rats were given a single oral dosage of 5000 mg/kg of VCO in the acute toxicity experiment