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Nature 203 , 10681069 (1964)

They provide a much stronger and longer-lasting signal than your bodys natural GLP-1 can produce on its own

2.6% placebo) 63% of participants lost at least 5% 33% lost at least 10% Approximately 14% lost 15% or more What this means practically: For someone weighing 220 pounds: Average result: 18 pounds lost (reaching 202 pounds) Good responder: 22-33 pounds lost (reaching 187-198 pounds) Excellent responder (uncommon): 33+ pounds lost Ozempic/Wegovy (Semaglutide) Weight Loss Results Semaglutides effectiveness was established in the STEP trials: STEP 1 trial (semaglutide 2.4mg): Average weight loss: 14.9% of body weight at 68 weeks (vs

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Now layer GLP-1 side effects on top: additional nausea, potential bloating , reduced appetite making it hard to consume the electrolytes and calories needed to manage keto adaptation, and potential fatigue from the medication itself

Addiction research has previously demonstrated that GLP-1 analogs alter the reward pathway in lab animals: mice get less of a dopamine hit from alcohol