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A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating

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Understanding these genetic predispositions helps clinicians anticipate which patients may benefit most from specific compounds or dosing strategies

Do not inject into a muscle (intramuscularly) or vein (intravenously)

They should also avoid alcohol, which can potentiate benzodiazepine effects