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Gain-of-function studies demonstrated that recombinant BDNF mimics might have beneficial effects on NSC transplantation, while loss-of-function studies showed that mice depleted of NSC-derived BDNF failed to improve cognition or restore hippocampal synaptic density (80)

Br J Nutr 113(8):12201227

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Through these integrated pathways, glutathione serves as a key regulator of brain cellular metabolism, supporting long-term neuronal function

Cytosolic synthesis of GSH takes place in two ATP-dependent reactions catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthase (GS)