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Expanding APEX2 substrates for proximity-dependent labeling of nucleic acids and proteins in living cells

Both GSSG and GSSR can be catalytically reduced back to GSH by the NADPH-dependent GSH reductase and thioredoxin (Trx)/glutaredoxin (Grx) system, respectively

As we age, our natural production of glutathione begins to decline, making supplementation an increasingly appealing option for many individuals

[49 50] Anderson et al

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