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298 Overall, G9a has context-dependent effects: it suppresses autophagy through H3K9me1/2-mediated gene silencing in metabolic and tumor stress settings, whereas under nutrient deprivation or ischemia, it supports autophagy by repressing mTOR

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The most common adverse effects, which occurred within 6 months of treatment and are dose dependent, are dizziness, drowsiness, pruritis, dry mouth, gastric discomfort, nausea and muscle tremor