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We employ a pancreatic -cell specific EGFR null mouse (-EGFR fx/fx ) and exogenous exendin-4 treatment to show a role for -cell EGFR in -cell mass, islet size, -cell proliferation, and insulin content

In lipidation, fatty acid chains are attached to the peptide, improving its pharmacokinetic properties

The increased surface HLA-I expression on -cells may be a driver of T1D pathogenesis, as self-reactive CD8 + T cells must recognize peptide-HLA-I (pHLA-I) complexes on -cells to trigger lysis

If you hit a weight target that is acceptable to you and your labs have improved, you should not feel pressured or need to increase the dose in pursuit of a lower weight

How we reviewed this article: Julie R

Is cinnamon efficacious for glycaemic control in Type-2 Diabetes Mellitus