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The SELECT trial (2023) demonstrated cardiovascular benefit over 5 years of treatment, supporting long-term safety in adults with obesity and established cardiovascular disease

The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role

The dose of PYY-based compounds was escalated at day 4 from 100 nmol kg 1 to 500 nmol kg 1

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Once you begin injecting from a pen, it can stay out for up to 28 days

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