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It must also be recognized that changes in protein binding may lead the unwary to believe there is a change in clearance when in fact drug elimination is not altered (see Box: Plasma Protein Binding: Is It Important?)

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Peroxynitrite induces haem oxygenase-1 in vascular endothelia to apoptosis

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[DOI] [PubMed] [Google Scholar] 281.Zhang J, Light AR, Hoppel CL, Campbell C, Chandler CJ, Burnett DJ, et al