The glutathione can then be degraded by the cytoplasmic ChaC family of -glutamylamine cyclotransferases [ChaC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and ChaC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)] generating 5-oxoproline and the dipeptide Cys-Gly
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GSH, in turn, acts as a cofactor for GPX4, a specialized enzyme responsible for preventing lipid peroxidation [78]
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People struggling with many addictions, ranging from opioids to gambling, are reporting similar experiences in clinics, on social media and around dinner tables
Preclinical observations also suggest generally reduced brain levels of the major antioxidant glutathione (GSH), albeit data are not entirely consistent [decreased (16, 1822)
