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Researchers have proposed two main theories

The same research team also examined the formulations impact of Curcuminoids (comprising curcumin) on serum inflammatory markers, specifically TNF- and IL-6, in a randomized, double-blind, placebo-controlled study involving 55 individuals with NAFLD

A 2025 Nature Communications paper mapped the binding to the disordered transactivation domain of p53, adding structural detail to how FOXO4-DRI engages its target

1 The incidence of antibody formation has been shown to decrease with time (over 3 years)