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GIP receptors are found in adipose tissue and the central nervous system, where they influence energy metabolism

Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )

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Although a dual agonist capable of activating both GLP1R and GIPR , Tirzepatide preferentially activates GIPR more, over GLP1R

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