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Protein injury can be quantified via carbonyls (DNPH derivatization), nitrotyrosine as an RNS-linked marker and advanced oxidation protein products, with MS-based identification/validation wherever feasible to improve specificity and DNA damage should include 8-oxoG, abasic sites and strand breaks, interpreted cautiously because activation of repair pathways (BER/PARP) can secondarily reshape metabolic readouts (e.g., NAD/ATP depletion) (Weber et al

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10.1016/j.vph.2011.05.001 [DOI] [PubMed] [Google Scholar] 194.Ceriello A, Esposito K, Testa R, Bonfigli AR, Marra M, Giugliano D