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THC is now considered a substance of abuse

Future research should prioritize tumor models to determine whether saponins can simultaneously enhance chemotherapys direct cytotoxic effects and rebuild antitumor immunity, thereby offering new strategies for preventing recurrence and improving long-term survival rates

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Variants that reduce CYP activity can slow initial metabolism, but if phase II is also impaired, reactive metabolites can still accumulate and damage DNA, mitochondria, and tissues like the liver and kidneys

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