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doi: 10.1007/s11306-015-0816-5 188 KennedyGSpenceVAMcLarenMHillAUnderwoodCBelchJJ

Clinical data show that higher plasma TMAO is associated with increased risk of major adverse cardiovascular events (MACE) and mortality (Wang et al., 2011

however, negative results have also been reported

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In addition, above the Na + -binding site (in the cavity, toward the extracellular side) we observe a second density that we have modelled as a water molecule (Fig