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Semaglutide subcutaneous injection (Ozempic) is also used to reduce the risk of non-fatal cardiovascular (CV) events and CV mortality in T2DM patients with CV disease

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Eur J Clin Invest 28:1946, PMID: 9568464 Kurdi M, Sivakumaran V, Duh RJ, Aon MA, Paolocci N, Booz GW (2012) Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes

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If this approach is unsatisfactory, medical therapy is the following step, and in some cases surgery might be considered

Mitochondrial membrane potential (MMP) assay The MMP was detected using JC-1 fluorescent probe (C2003S, Beyotime, Shanghai, China)