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Diabetic neuropathy can be asymptomatic in some patients, but it may manifest as paresthesias, burning sensations, and numbness in the feet

What they're saying: "People with obesity and knee osteoarthritis often live with pain and restricted mobility, and may eventually require total joint replacement," Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health, said in a statement

No cases of pancreatitis, thyroid C-cell tumours, or severe hypoglycaemia were reported in the Phase 2 cohort at any dose

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Rotate application sites : Do not apply consecutive patches to exactly the same location

Some analyses show a reduced risk of pulmonary embolism with GLP-1 use, while one 2025 meta-analysis found a significantly higher DVT risk in patients who had been on these medications for more than 78 weeks