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synthesized two amphiphilic molecules mPEG-TK-DA and DTPA-N10-10 with ROS-scavenging functions, and self-assembled AGL through hydrophobic and hydrophilic interactions, forming multi-site ROS-scavenging nanoparticles called PDN@AGL

Abbreviations AChE: Acetylcholinesterase Bti : Bacillus thuringiensis israelensis CHC: Cuticular hydrocarbon CPR: NADPH-cytochrome P450 reductase CYP: Cytochrome P450 DDT: Dichlorodiphenyltrichlorethane F: Phenylalanine GABA: -Aminobutyric acid GST: Glutathione S -transferases H: Histidine kdr : Knockdown resistance L: Leucine LLINs: Long-lasting insecticide nets PBA1c: 3-Phenoxybenzyl alcohol PBA1d: 3-Phenoxybenzaldehyde PBAcid: 3-Phenoxybenzoic acid RDL : Resistance to dieldrin gene S: Serine Vssc: Voltage-sensitive sodium channel References World Health Organization

In addition, mazdutide reduced liver fat content in adults with overweight or obesity

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Among the 18% of adults who report having ever used GLP-1 drugs, the vast majority (84%) say they have been diagnosed with at least one of the predominant conditions these drugs are prescribed to treat, including obesity or being overweight in the past five years (77%), or ever being diagnosed with diabetes (49%) or heart disease (21%)