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Blood Pressure and Lipids Both medications produce similar improvements in cardiovascular risk factors: Blood pressure: Both typically reduce systolic BP by 3-6 mmHg Effects are similar between medications Lipids: Both reduce triglycerides Modest effects on LDL cholesterol Similar lipid improvements Metabolic Comparison Cost and Insurance Cost considerations may influence medication choice for some patients

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In combination with insulin (with or without metformin), JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)

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Anti-Inflammatory Effects Beyond Weight Reduction GLP-1 receptors exist throughout the immune system, including on specialized white blood cells that regulate inflammation