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Several studies have demonstrated reduced absorption of bile acids in patients receiving metformin treatment and shown this to be a direct effect of metformin on enterocytes [65, 7275]

Proc Natl Acad Sci 98(23):1292012925 Rhee SG, Chae HZ, Kim K (2005) Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

doi: 10.1016/j.pupt.2014.05.002 141 MobarraN.ShanakiM.EhteramH.NasiriH.SahmaniM.SaeidiM.et al

While gut-hormone-based multi-agonists have great therapeutic potential, the conceptual approach to multi-agonism is not limited to incretin hormones, or even to structurally related peptides

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