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Such barriers have contributed to the use of compounded forms of GLP-1/GIP receptor agonists, which are not recommended by the FDA

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Important safety considerations include a boxed warning for medullary thyroid carcinoma risk and contraindication in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Eat Enough Protein: GLP-1 drugs often blunt your appetite, which can be a double-edged sword

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The decision depends on factors such as: Starting BMI Weight-loss history Type 2 diabetes or insulin resistance Surgical and anaesthetic risk Medication tolerance Patient preference Long-term treatment goals NICE also emphasises that bariatric surgery assessment should involve a multidisciplinary team with medical, nutritional, psychological and surgical expertise