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For instance, cigarette smoke contains a complex mixture of free radicals and pro-oxidants

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Clinical, Cosmetic and Investigational Dermatology, 10 , 147

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And a lot of people just stay there

The cause of hepatic disease has been thought to be multifactorial in the setting of congestive hepatopathy from heart failure, malnutrition, previous or concomitant liver disease (i.e., infectious or autoimmune disease), and drug related liver injury, and possible liver ischemia from a mismatch between oxygen consumption and oxygen delivery to the liver (395-399)