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An early work, presented in 1995 by Dentico and colleagues, evaluated the effect of 30-day administration of high doses of intravenous or intramuscular GSH on liver cytolysis indexes in patients with chronic steatosic liver disease (77)

One of the transcription factors established as able to bind EpRE is Nrf2, which located in the cytosol through the inhibitory interaction with Keap1 in resting cells