As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity
New England Journal of Medicine, 365(25), 23822388
Evidence comparison: BPC-157 has a broader preclinical evidence base spanning gastrointestinal, musculoskeletal, neurological, and cardiovascular injury models
Thuc Gluthion 1200 mg c tc dng g
CagriSema combines semaglutide with cagrilintide (an amylin analog) and is advancing through trials
This means we have limited data on the long-term effects of these drugs on humans