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This makes things difficult

Subsequently, in the large randomised placebo-controlled FIDELIO-DKD trial including adults with type 2 diabetes and CKD, finerenone reduced the risk of the primary kidney outcome (a composite of kidney failure, sustained eGFR decline 40% or kidney death) by ~20% [69]

Studies on IV therapy and IV vitamin therapy in Vancouver, suggest that direct doses of nutrients can help improve various conditions, and reduce nutritional deficiencies in patients

However, these trials were not specifically designed to assess bone density changes or fracture risk as primary outcomes

The FDA will want to understand this signal fully before approving the drug

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