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Specific pathogenic bacteria, such as Campylobacter, Escherichia coli, Salmonella and Shigella, produce a toxin called Cytolethal Distending Toxin B (CdtB)

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AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M

The development of the implantation theory for the origin of peritoneal endometriosis

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