According to NICE guidance on type 2 diabetes management (NG28), treatment should be individualised, and medications causing intolerable side effects should be reviewed
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State licensing rules limit which medications can be prescribed based on clinician and pharmacy jurisdiction
Recent Developments In September 2025, Eli Lilly released data showing orforglipron lowered A1C by 2.2 % vs 1.4 % for oral semaglutide at highest doses
Among those who had heard of the drugs, 13 percent had learned about them from an AI tool, including 8 percent who had looked up GLP-1 information using AI and 6 percent who had learned by chance (respondents could choose more than one answer)
Your medical history, budget, and guidance from your healthcare provider will determine which option is the right fit for your treatment plan