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Journal of Clinical Gastroenterology, 55 (4), 279299

Preclinical models show that GLP-1 agonists can reduce neuroinflammation by dampening microglial activation and decreasing pro-inflammatory cytokines, suggesting potential applications in protecting against neurodegenerative diseases like Alzheimer's and Parkinson's disease

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In the future, more GLP-1RAs will be explored for the improvement of ischemic stroke and cognitive impairment in patients with diabetes [190]

The dosing can be customized allowing more nuanced micro-dosing

Retatrutide represents a newer category of metabolic therapy currently under clinical investigation