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This chemosensor is expressed by the pancreatic -cells where its signaling activates Gs proteins and induces the secretion of GLP-1 directly through Epac proteins and indirectly via CREB mediated expression of Psck1, while in -cells mediates insulin release [(100)

Material and methodsRegistration This meta-analysis was performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting systematic reviews.12 This systematic review was registered in PROSPERO [CRD42023485460]

The overlap may provide additive effects, particularly during challenging phases such as holiday seasons or weight plateaus