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Duarte JM, Agostinho PM, Carvalho RA, Cunha RA (2012) Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice

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Only about 30 humans have ever been studied, all by one doctor, with no control groups

Based on the Phase 2 trial protocol, dose increases occurred every four weeks

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