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Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology

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Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S et al

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A structured fasting protocolsuch as 16:8 (16 hours fasting, 8-hour eating window) or 5:2 (normal eating five days, 500-calorie days twice weekly)can create a larger calorie deficit while GLP-1 reduces cravings and hunger signals