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In essence, while STING normally aids innate immunity, its overactivation in the brain can harm neuronal health and accelerate Alzheimers progression via sustained neuroinflammation and microglial dysfunction

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showed expression of toll-like receptor 9 (TLR9) in intact erythrocytes, mediating the capability to bind bacterial and plasmodial cell-free DNA, as well as synthetic CpG DNA [55]

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