5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids
NCT03914326) randomized 9650 participants with type 2 diabetes and atherosclerotic cardiovascular disease and/or chronic kidney disease to oral semaglutide or placebo
"The somatostatin-28(1-12)-NPAMAP sequence: an essential helical-promoting motif governing prosomatostatin processing at mono- and dibasic sites"
So the likelihood of this being a chance finding is infinitesimally small, and I think we can be highly confident that the results are robust and real. Three other drug treatments have been shown to provide benefits for people with diabetic kidney disease, and the researchers note in the new study that clinicians and patients will need to consider the order and priority of use for semaglutide. A combination of therapies could be important, and many of the trial participants were also receiving some other type of treatment for their diabetes
It isnt safe if you also have Multiple Endocrine Neoplasia pattern type 2 (MEN 2)
Compounded GLP-1 Costs Brand-name Ozempic typically costs $900$1,500 monthly without insurance, while GLP-1 competitor Wegovy ranges from $1,100$1,400 per injection pen
