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One important pathway involved is the PI3K/AKT signaling cascade, which has been shown to reduce tau hyperphosphorylation and neurofilament protein accumulation, thereby protecting against memory impairment (Wang Y

We are grateful to Brian Kraemer for preliminary data, Jadwiga Forster for technical assistance, and Laura Vanderploeg and Anne Helsley-Marchbanks for assistance with figure and manuscript preparation

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