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Apoptotic cell bodies: Lymphocytes from SLE patients frequently experience accelerated apoptosis, releasing nuclear antigens like nucleosomes into the extracellular space, which can then trigger immune responses and autoantibody formation (84)

Interestingly, sustained activation of ROS can trigger various forms of programmed cell death, including apoptosis, ferroptosis, pyroptosis, necroptosis, oxeiptosis, NETosis, parthanatos, autophagy, necrosis and immunogenic cell death [22, 213, 214] (Fig

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Clinical studies show that vitamin injections, such as vitamin B12 shots , deliver nutrients more efficiently than pills, with noticeable improvements in energy, cognition, and mood