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Individuals with a history of depression, anxiety disorders, bipolar disorder, or previous suicidal thoughts or attempts should be carefully evaluated before initiating therapy

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If severe reactions persist, discuss switching injection sites with your doctor

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There are, however, instances in which the enhanced metabolism may generate metabolites that are directly (or indirectly) hepatotoxic or toxic to other organs (e.g., metabolism of chloroform to form phosgene

Ikramuddin S, Korner J, Lee W-J et al (2018) Lifestyle intervention and medical management with vs without roux-en-y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic blood pressure at 5 years in the diabetes surgery study