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The trial portfolio included three single-dose pharmacokinetic studies and three multiple-dose efficacy trials

Metformin, a common diabetic drug is also a cause of B12 deficiency

Patients with pernicious anemia have about three times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated

Avoid smoking and limit alcohol consumption, as these can negatively impact healing and implant success

Sublingual delivery can in principle bypass first-pass hepatic metabolism by absorbing through the oral mucosa directly into systemic circulation