[Abstract] mBio
In the SUSTAIN program, 83 patients (1.4%) treated with semaglutide developed a gallbladder event, compared with 39 patients (1.9%) in the placebo group ( versus 0.1% with placebo), while the risk of cholecystitis was similar (data derived from the summary of product characteristics (SmPC) (87), as the manuscripts did not describe these data)
Review total dose, ingredient overlap, stability, target population and substantiation for the exact finished product
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At the molecular level, semaglutide has both pro-thrombotic effects (primarily through dehydration, muscle loss, and B12 depletion) and anti-thrombotic effects (through direct platelet inhibition, nitric oxide enhancement, anti-inflammatory pathways, and PAI-1 modulation)