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It directly neutralizes reactive oxygen and nitrogen species, regenerates the oxidized forms of vitamin C and vitamin E (restoring their antioxidant activity), and serves as a cofactor for glutathione peroxidase enzymes that reduce hydrogen peroxide and lipid peroxides

This trajectory mirrors aspects of human hepatic ontogeny, where hepatoblasts differentiate into functional hepatocytes and cholangiocytes before a subsequent phase involving mesenchymal cell expansion 32

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Regulation of ferroptotic cancer cell death by GPX4

Erythrocytes affect hemostasis and thrombosis by altering blood viscosity, blood flow dynamics, secreting RBC-derived microvesicles, interactions with platelets or endothelial cells, fibrinogen-induced RBC aggregation, activation of blood coagulation factors, direct modulation of thrombin and fibrin formation, or formation of polyhedral-like erythrocytes in thrombi [47,48,49]

In: Floh L (ed) Series Oxidative stress and disease