Loneliness Social isolation Lack of meaningful purpose in life Lack of sleep Lack of exercise or excessive exercise Relationship conflicts Gut dysbiosis Dental infections Autoimmunity Lack of physical affection Environmental toxins Some of the above may surprise you but all of these need to be seriously confronted if they are present
10.1016/j.ccm.2013.09.005 16 CheW.Lerner-MarmaroshN.HuangQ.OsawaM.OhtaS.YoshizumiM.et al (2002)
Although drugs only account for 0.1%2% of AP cases, their impact can be life-threatening (Wolfe et al., 2020)

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