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Science 351 , 12141218 (2016)

This dual-action mechanism is a key distinguishing feature of tirzepatide , setting it apart from other weight-loss and diabetes drugs, like Ozempic or Wegovy, that can target only one of these two hormones and, therefore, only one aspect of metabolic regulation

As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis

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Use a sterile syringe and ensure proper disinfection before administration