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Intellectual Property 20.1

A pair of studies conducted by Vinogradova et al

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Similar results were confirmed by in vivo study on orthotopic xenograft mouse model [82]

Insulin glargine was initiated at 10 U once daily and adjusted weekly throughout the trial using a treat-to-target algorithm based on self-measured fasting blood glucose values

There is also a critical need for well-designed long-term safety studies addressing the potential side effects of chronic polyphenol supplementation, as current data are mainly limited to short-term animal experiments or isolated compounds, and results from these do not always translate directly to humans (121)