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They used population pharmacokinetic/pharmacodynamic (PK/PD) modeling to analyze tesofensine and its metabolite, as well as cognitive assessment scale data from 62 mild AD patients in placebo-controlled studies

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doi:10.3389/fendo.2020.00500

In the placebo group, the dogs did not receive pimobendan until they reached CHF, while in the pimobendan group, the dogs were started on the pimobendan from day one

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