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Neuroprotection: Exploring the role of increased NAD+ and mitochondrial integrity in supporting cognitive focus and neuronal resilience

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Translational Considerations and Safety NNMT has emerged as a systems-level regulator linking methylation capacity, NAD biology, and adipocyte energetics

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Diagnosis typically involves blood tests including full blood count (showing macrocytosis), anti-intrinsic factor antibodies (which are specific for pernicious anaemia), and sometimes anti-parietal cell antibodies

Early work, including in the Journal of Medicinal Chemistry, has mapped these relationships to guide the design of next-generation NNMT inhibitors