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Retatrutide is an investigational triple agonist peptide that targets the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously

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These medications work by mimicking natural incretin hormones, which slow gastric emptying, enhance insulin secretion, suppress glucagon release, and reduce appetite through central nervous system pathways

inhibition has been shown to reduce adipose mass in diet-induced obese mice

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