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Tirzepatide is a dual agonist targeting both GLP-1 and GIP receptors, while semaglutide targets only GLP-1

Rats ( n = 14/group) were assigned to receive once-daily IP injections at the beginning of the onset of the dark cycle of vehicle (1 ml/kg), amylin (5 g/kg), GLP-1 (100 g/kg) or a combination of amylin and GLP-1 10,15,33,65,71,72,73,74

6B and C)

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