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Moreover, many tumors including PCa cells shed DNA into the serum or other easily accessible body fluids (e.g., semen, urine), simplifying the detection of GSTP1 epimutations in early tumorigenesis stages

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The diagnosis of MC is mainly based on the observation of brown pigment deposits in the colorectal mucosa under the microscope or the presence of brown granules in the cytoplasm of submucosal macrophages