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The TB-500 sequence , Ac-LKKTETQ-EKNPLPSKETIEQEKQ-NH2 in its full designation, with the core actin-binding motif LKKTETQ representing the Thymosin Beta-4 domain responsible for G-actin interaction , captures the biologically active region of Thymosin Beta-4 responsible for its actin sequestration function and the downstream cellular biology that flows from regulation of actin polymerisation dynamics