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(PubMed) Mahmoud NN, Carothers AM, Grunberger D, et al

In research settings, GHK-Cu is used to investigate copper-dependent tissue remodeling and repair pathways, including extracellular matrix regulation (e.g., collagen/proteoglycan balance and matrix metalloproteinase activity) and wound-repair signaling in cellular and tissue models

Additionally, LL-37 can undergo proteolytic processing to release smaller bioactive fragments with distinct functions (Bowdish et al., 2005)

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The off-window gives receptor and pathway signaling a reset and prevents open-ended, indefinite use